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KMID : 0923620190190060039
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Immune Network
2019 Volume.19 No. 6 p.39 ~ p.39
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Lactobacillus pentosus Modulates Immune Response by Inducing IL-10 Producing Tr1 Cells
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Kim Jung-Eun
Sharma Amit
Sharma Garima
Lee So-Young
Shin Hee-Soon
Rudra Dipayan
Im Sin-Hyeog
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Abstract
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Several gut commensals have been shown to modulate host immune response. Recently, many food derived microbes have also been reported to affect the immune system. However, a mechanism to identify immunostimulatory and immunoregulatory microbes is needed. Here, we successfully established an in vitro screening system and identified an immunoregulatory bacterium, Lactobacillus pentosus KF340 (LP340), present in various fermented foods. LP340 induced a regulatory phenotype in mice Ag presenting cells which, in turn, induced IL-10 and IFN-γ producing Type 1 regulatory T cells (Tr1 cells) from naive CD4+ T cells. Naive CD4+ T cells co-cultured with LP340 treated dendritic cells highly expressed cytokine receptor IL-27R and were CD49b and lymphocyte-activation gene 3 double positive. Oral administration of LP340 in mice with atopic dermatitis reduced cellular infiltration in affected ear lobes and serum IgE levels, thus, ameliorating the disease symptoms. This suggests a systemic immunoregulatory effect of LP340. These findings demonstrate that LP340, a bacterium derived from food, prevents systemic inflammation through the induction of IL-10 producing Tr1 cells.
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KEYWORD
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Tr1 cells, Lactobacillus pentosus, Interleukin-10, IL-10, Atopic dermatitis
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